[HTML][HTML] Estimating efficacy and drug ED50's using von Frey thresholds: impact of weber's law and log transformation
C Mills, D LeBlond, S Joshi, C Zhu, G Hsieh… - The Journal of …, 2012 - Elsevier
The use of von Frey filaments, originally developed by Maximilian von Frey, has become the
cornerstone for assaying mechanical sensitivity in animal models and is widely used for
human assessment. While there are certain limitations associated with their use that make
comparisons between studies not straightforward at times, such as stimulus duration and
testing frequency, von Frey filaments provide a good measurement of mechanosensation.
Here we describe the application of von Frey filaments to testing in animal models …
cornerstone for assaying mechanical sensitivity in animal models and is widely used for
human assessment. While there are certain limitations associated with their use that make
comparisons between studies not straightforward at times, such as stimulus duration and
testing frequency, von Frey filaments provide a good measurement of mechanosensation.
Here we describe the application of von Frey filaments to testing in animal models …
